Skip to main content
. 2023 Mar 27;46(3):133–141. doi: 10.14348/molcells.2023.0028

Fig. 3. Model for the multiple stress-sensing mechanisms acting through KEAP1.

Fig. 3

There are five classes of NRF2 inducers: Class I, Cys151-preferring; Class II, Cys288-preferring; Class III, Cys151/Cys273/Cys288-selective; Class IV, Cys226/613/622/624-preferring; and Class V, Non-electrophilic KEAP1-NRF2 PPI inhibitors. Chemicals representing each class are shown. KEAP1, Kelch-like ECH-associated protein 1; NRF2, NF-E2-related factor 2; DEM, diethylmaleate; tBHQ, tert-butyl hydroquinone; DMF, dimethylfumarate; NO, nitric oxide; SFN, sulforaphane; CDDO-Im, 1-[2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl]-imidazol; OA-NO2, nitro-octadec-9-enoic acid; 4-HNE, 4-hydroxy-nonenal; 15d-PGJ2, 15-deoxy-∆12,14-prostaglandin J2; H2O2, hydrogen peroxide; CUL3, CULLIN 3; PPI, protein-protein interactions.