Fig. 3.

Landscape of biological features associated with immunotherapy response. Cancer cell intrinsic and extrinsic features, including host immunity, impact the effectiveness of immune checkpoint inhibitors targeting the PD-1/PD-L1 axis. The features reported are associated to resistance or sensitivity in either TNBC and other cancer types (bold contoured boxes) or exclusively in other cancer types (thin contoured boxes). Comprehensive assessment of such factors may be pivotal to select patients that are more likely to respond to ICI. (Adapted and updated from Bianchini et al. Nat Rev Clin Oncol 2022).