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. 2023 Apr 3;13:5425. doi: 10.1038/s41598-023-32045-1

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Gene enrichment analysis for 3 significantly downregulated genes (PTGS1, PTGS2 and CX3CL1) in bovine endometrial cells after incubation with HF-EXO compared to the control (A) STRING protein n-protein interaction (PPI) analysis (B) Gene ontology (GO) enrichment for biological processes, molecular function and cellular component revealed highest enriched GO terms relate to reproduction and inflammation. Fisher’s exact test was used for GO annotations. The corrected P-value was calculated to false discovery rate (FDR), FDR < 0.0001.