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. 2023 Feb 17;128(8):1559–1571. doi: 10.1038/s41416-023-02208-y

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a ALK mutation frequencies in relapsed neuroblastoma. b Age at diagnosis of patients with ALK-mutated versus non-mutated relapsed neuroblastoma. c ALK amplification frequencies in relapsed neuroblastoma. d Age at diagnosis of patients with ALK-amplified versus non-amplified relapsed neuroblastoma. Boxplots show the median, first, and third quartile (boxes), with whiskers indicating the minimum and maximum of the data within 1.5× the interquartile range. P values for a and c were calculated using Fisher’s exact test or Chi-squared test where appropriate, and for b and d using Wilcoxon–Mann–Whitney test. HR, high-risk; NHR, non-high-risk; ampl, amplified; m, months; St4, stage 4; loc, localized disease.