Fig. 5.

hAMSC-Exos facilitated cutaneous wound healing and increased the capillary density in rats. A Gross views of wounds treated with NC + PBS, DM + PBS and DM + hAMSC-Exos at Days 0, 7, 10 and 14 postoperation. B Quantitative analysis of the wound closure rates for each group at the indicated times. C Representative images of immunohistochemical staining for CD31 in wound sections treated with NC + PBS, DM + PBS and DM + hAMSC-Exos. D Quantitative analysis of the loop numbers for each field in every group. NC normal control, DM diabetes mellitus. *p < 0.05, NC + PBS compared with DM + PBS; ^#p < 0.05, DM + hAMSC-Exos compared with DM + PBS, n.s. no significance