Fig. 4.

V₂C-TAT@Ex-RGD for low-temperature nucleus-targeted PTT in the near-infrared-II region. A Schematic diagram showing the preparation and dual targeting ability of V₂C-TAT@Ex-RGD. B Biodistribution of V in main tissues and tumor 24 h in MCF-7 tumor-bearing mice after intravenous injection. C Infrared thermal images at the tumor sites of the MCF-7-tumor-bearing mice under laser irradiation after different treatments. D Relative tumor growth curves of the MCF-7 tumor- bearing mice in different groups. E H&E and TUNEL staining of pathological changes in tumor tissues from different groups.

(Adapted from Cao et al. ACS Nano. 2019;13:1499–510, with permission from American Chemical Society [113])