Fig. 5.

Aptamer-modified siRNA-loaded exosomes treatment suppresses prostate tumor proliferation and metastasis. A Schematic illustration of the procedure for the E3 aptamer-modified siRNA loaded exosomes. B Fluorescence images of tumor- bearing (subcutaneous implantation of PC3 cells) or no tumor-bearing mice after the injection of aptamer-modified, DIR-labeled exosomes. C Representative image of the subcutaneous tumors in mice after treatment with aptamer-modified siRNA-loaded exosomes compared with the control group. D, E Immunohistochemistry staining of Vimentin, Cleaved Caspase-3 and Ki67 in tumor tissues treated with aptamer-modified siRNA-loaded exosomes. F The weight of tumor in orthotopically implanted mouse model after treatment with aptamer-modified siRNA-loaded exosomes compared with the control group. G Full-scale H&E staining of livers from the orthotopic mouse model. Metastatic nodules in livers were dissected counted.

(Adapted from Han et al. Theranostics. 2021;11:6526–41, with permission from Ivyspring International Publisher [116])