Fig. 9.

Smart exosome-based system applied in Bmp7 targeting delivery for omental adipose tissue browning. A Schematic illustration of exosome-based Bmp7 delivery system SmartExo@Bmp7 construction. B Schematic diagram of the experimental procedure. C Representative confocal images of DiI-labeled exosomes (red) in abdominal adipose tissue of mice with or without ultrasound irradiation. D Average weight of each group recorded starting from the high fat diet to the end of treatment period. E Representative images of H&E staining of omental adipose tissue. F Relative area of lipid droplets for HE staining images and relative expression level of Ucp1 in omental adipose tissue. G Representative images of Ucp1 staining of omental adipose tissue.

(Adapted from Guo et al. J Nanobiotechnology. 2021;19:402, with permission from Springer Nature [145])