Gomes 2012.

Study characteristics
Methods	Randomised, single‐blinded controlled trial Assessors were blinded to the treatment groups.
Participants	Infants aged from 28 days to 24 months, previously healthy, with a clinical diagnosis of acute bronchiolitis infection and positive outcome of RSV in nasopharyngeal aspirate detected by immunofluorescence technique. Country: Brazil. N = 30 participants randomised, 30 participants analysed at baseline, 20 analysed at 48 hours, 17 analysed at 72 hours Mean age 125 days. % RSV+ 100%
Interventions	Group 1: new physiotherapy group received prolonged slow expiration (slow passive and progressive expiration from the functional residual capacity into the expiratory reserve volume) and clearance rhinopharyngeal retrograde (forced inspiratory manoeuvre) (N = 10) Group 2: conventional physiotherapy group received vibrations, expiratory compression, modified postural drainage only in the lateral decubitus position, and clapping (N = 10) Group 3: control group received suction of the upper airways (N = 10). The control group was only assessed at admission, and afterwards followed the standard chest physiotherapy regimen in the hospital; we did not consider this group in the review.
Outcomes	Primary outcome: Wang's clinical score. Higher values indicate increased severity. Secondary outcomes: transcutaneous PCO2
Notes	Assessments performed at 2 hours, 48 hours, and 72 hours after admission and again 1 hour prior to discharge. ClinicalTrials.gov identifier: NCT00884429 No information on funding Authors contacted and provided information (21 March 2014).
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	"Infants were randomised by using sealed opaque envelopes containing the instructions to be followed in each of three groups"
Allocation concealment (selection bias)	Low risk	"Infants were randomised by using sealed opaque envelopes containing the instructions to be followed in each of three groups"
Blinding (performance bias and detection bias) All outcomes	Low risk	"Assessors were blinded to the treatment groups. These raters were trained specifically for this assessment. The time spent caring for children was similar in all groups and parents were unaware of their child's group allocation."
Incomplete outcome data (attrition bias) All outcomes	Low risk	3 participants lost at 72 hours (1 in new physiotherapy group and 2 in conventional physiotherapy group) due to hospital discharge.
Selective reporting (reporting bias)	Unclear risk	Study protocol was published on ClinicalTrials.gov, and methods agree with publication. The protocol describes the study as single‐blind (investigator), although the publication states that parents were also blinded to the intervention assignment.
Other bias	Low risk	No other biases identified.