Table 1.
p53 induced pathologies in mouse tissues.
| Mouse Genotype | p53 induced pathologies/tissues affected | Rescue/Reversal | Ref. |
|---|---|---|---|
| Mdm2Puro/∆7-12 |
Lymphopoiesis defects Radiation sensitivity (8 Gy WBI) |
NP NP |
[59] [62] |
| Mdm2PND |
Hyperpigmentation in extremities Gonadal atrophy (small testis, follicular defects) Radiation sensitivity (3 Gy WBI) |
Kitl ↓ or p53+/− p53+/− or Puma−/− p53+/− or Puma−/− |
[60] |
| Mdm2P2/P2 |
Radiation sensitivity (6 Gy WBI), BM ablation Radiation resistance (17 Gy SBI), no GI toxicity |
Puma−/− p21−/− |
[75] [78] |
| Mdm25AA | Radiation sensitivity (6 Gy WBI), fertility defects | NP | [61] |
| Super p53 | Radiation resistance (13.4 Gy SBI), no GI toxicity | p21−/− | [79] |
| Mdm2−/−p53ERTAM |
Apoptosis in radiosensitive tissues Inhibition of cell proliferation in apoptosis-resistant tissues |
NP | [67] |
| Mdm4−/−p53ERTAM | Mild/reversible apoptosis and cell proliferation defects in tissues | NP | [55] |
| Mdm2 FM/−;CAG-CreER |
Lethal with severe pathologies in major tissues after four days post Tamoxifen injection Atrophy of splenic white pulp, BM depletion, villus atrophy and crypt apoptosis |
p53−/− | [72] |
| Mdm2 FM/−;CAG-CreER |
Tissue necrosis in pancreas, kidney and intestine 24 hours post Tamoxifen injection No noticeable defects in ovary and heart |
NP | [73] |
NP not performed, BM bone marrow, GI gastrointestinal, WBI whole body irradiation, SBI shielded body irradiation.