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. 2023 Apr 3;6:363. doi: 10.1038/s42003-023-04747-9

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a PCA plot of DAR from ATAC-seq data. b Heatmap displaying DAR z-score normalized across samples. c Scatter plots showing log₂-fold changes (FC) of MTC subsets vs. naïve T cells of DEG (x-axis) mapped to DAR (y-axis) for CD8⁺ T_CM, CD8⁺ T_EM, and CD8⁺ T_EMRA. Dotted lines represent ±1 log₂FC. d Genome plots showing the average accessibility levels in each of the memory subsets and naïve T cells at the indicated locus. Data represent the mean of each cell type. DAR are highlighted by boxes. e Volcano plots showing DAR that are more accessible in CD4⁺ T_EM vs CD4⁺ T_CM, CD8⁺ T_EM vs CD8⁺ T_CM, and CD8⁺ T_EMRA vs CD8⁺ T_EM. Number of DAR in each direction are totaled at the top of each plot.