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. 2023 Apr 3;6:363. doi: 10.1038/s42003-023-04747-9

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Network diagram showing transcription factors in CD4⁺ MTC highly ranked by PageRank and associated connections to other TF. Triangles represent log₂FC (size) and direction (orientation) of PageRank as indicated in the legend. Arrows represent putative regulation via nearby binding motifs. AHR, HIF1A, MSC, and other memory-subset defining TFs are highlighted in yellow. b Network diagram as in (a) for CD8⁺ T_CM and T_EM. c GSEA plot using gene set made up of genes putatively regulated by AHR showing enrichment in CD8⁺ T_CM vs. T_EM DEG. d Heatmap of leading-edge genes from GSEA most highly upregulated in T_CM. Bar plot indicates normalized expression of AHR in rpkm. Data represent the mean expression of each cell subset. e Genome plots showing the average accessibility levels in each of the CD8⁺ memory and naïve T cells at the indicated locus. DAR are highlighted by black horizontal bars, with AHR and HIF1A binding motifs at indicated locations. Data represent the mean of each cell type.