Fig. 2. Genes of interest exhibit circadian properties in human healthy muscle tissue and cells which are altered upon CLOCK^KD.

Scatter plot depicts the distribution of circadian (~24 h) genes of interest in (a) muscle biopsies collected from nine healthy participants and (b) myotubes cultured cells from two healthy control donors (upper panel) and siRNA transfected CLOCK^KD cells (lower panel). c STRING network depicts the interaction between differential rhythmic genes due to CLOCK^KD and the core-clock genes (red circles). d Circular heatmap visualizes the differentially expressed genes of interest due to CLOCK^KD vs. WT in donor 1 (upper panel) and donor 2 (lower panel).