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. 2023 Mar 21;14:1136669. doi: 10.3389/fimmu.2023.1136669

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Copyright © 2023 Lin, Jamin, Wolfheimer, Fiedler, Junker, Goretzki, Scheurer and Schülke

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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rFlaA: Betv1 induces IL-1β and pro-inflammatory cytokine secretion from both human and mouse macrophages. C57BL/6J peritoneal macrophages (A), human buffy coat-differentiated macrophages (B), or PMA-differentiated THP-1 macrophages (C) were stimulated with either LPS as a positive control or the indicated equimolar amounts of either rBet v 1, rFlaA, rFlaA + rBet v 1, or rFlaA:Betv1 for 24 h. Supernatants were collected and checked for the secretion of IL-1β, IL-6, IL-12, and TNF-α by ELISA. Data are the mean results ± SD from either three independent experiments (A, C) or samples collected from four donors (B). Statistical significances are indicated as **: p-value < 0.01, ***: p-value < 0.001.