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. 2023 Mar 21;14:1136669. doi: 10.3389/fimmu.2023.1136669

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Copyright © 2023 Lin, Jamin, Wolfheimer, Fiedler, Junker, Goretzki, Scheurer and Schülke

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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rFlaA:Betv1 induced IL-1β-, IL-6-, and TNF-α-secretion is dependent on the IL-1β-IL1R1 autocrine pathway in mouse peritoneal macrophages. Peritoneal macrophages isolated from either C57BL/6J-, TLR5^-/–, or IL1R^-/–mice were stimulated with either LPS as a positive control or equimolar amounts of either rFlaA + rBet v 1 or rFlaA:Betv1 for 96 h (A). Supernatants were collected and checked for the secretion of IL-1β, IL-6, and TNF-α by ELISA (B). Data are the mean results of three independent experiments ± SD, and statistical significances are indicated as ns: p-value > 0.05, *: p-value < 0.05, **: p-value < 0.01, ***: p-value < 0.001.