Table 1.
Characteristics of COVID-19 patients by ultimate disease severity.
| Ambulatory or hospitalized with mild disease | Severe disease or death | P-value | |
|---|---|---|---|
| N=60 | N=17 | ||
| Age (years) | 55 ( ± 17) | 70 ( ± 12) | <0.01 |
| Male Sex | 60% | 53% | 0.78 |
| Diabetes | 29% | 59% | 0.04 |
| Chronic Kidney Disease | 6.9% | 17.6% | 0.19 |
| Dialysis Dependence | 3.4% | 0.0% | 0.99 |
| Liver Failure or cirrhosis | 5.0% | 5.9% | 0.99 |
| Prior MI or CHF | 8.3% | 0.0% | 0.58 |
| Hemoglobin (g/dL) | 14.2 (2.0) | 14.3 (2.0) | 0.87 |
| Platelet Count (x109/L) | 236 (184–314) | 203 (156-261) | 0.09 |
| International normalized ratio | 1.0 (1.0-1.1) | 1.1 (1.0-1.1) | 0.17 |
| PTT (s) | 29 (25-31) | 27 (25-31) | 0.81 |
| Fibrinogen, (mg/dL) | 466 (347-579) | 594 (507-720) | <0.01 |
| D-dimer (ug/dL) | 0.7 (0.4-1.4) | 1.4 (1.0-2.5) | 0.01 |
| Creatinine (mg/dL) | 0.8 (0.7-1.1) | 0.8 (0.6-1.1) | 0.81 |
| Vent Free Days to 30 days | 30.0 (30.0-30.0) | 14.0 (3.0-30.0) | <0.01 |
| Admission Acuity | <0.01 | ||
| Emergency department only | 45.0% | 0.0% | |
| Floor | 48.3% | 11.8% | |
| Intensive care unit | 6.7% | 88.2% | |
| APACHE III Score | 27 (17-42) | 59 (52-73) | <0.01 |
| Venous Thromboembolism | 3% | 18% | 0.07 |
| Disease Severity at Day 7 (WHO Ordinal Scale) | <0.01 | ||
| Ambulatory | 72% | 0% | |
| Hospitalized, mild disease | 28% | 0% | |
| Hospitalized, severe disease | 0% | 88% | |
| Death | 0% | 12% | |
| Mortality at Discharge | 1.7% | 41.2% | <0.01 |
MI, myocardial infarction; CHF, congestive heart failure; APACHE-III, Acute Physiology and Chronic Health Evaluation III score; venous thromboembolism, deep vein thrombosis or pulmonary embolism.