Table 2.

Comparison of thromboinflammatory biomarkers among patients with COVID-19 by ultimate disease severity.

	Ambulatory or hospitalized with mild disease	Severe disease or death	Unadjusted p-value	Sidak-Holm Adjusted p-Value
Log SARS-CoV-2 Antigen (pg/ml)	7.1 (5.3-8.2)	9.1 (8.5-9.8)	<0.01	<0.01*
Inflammatory/Endothelial Biomarkers
Log RAGE (pg/ml)	7.1 (6.5-7.9)	8.7 (8.3-9.1)	<0.01	<0.01*
Log TREM-1 (pg/ml)	5.2 (4.8-5.6)	5.7 (5.5-5.8)	<0.01	0.06
Log IL-6 (pg/ml)	3.2 (2.3-3.8)	4.4 (3.8-4.6)	<0.01	<0.01*
Log IL-8 (pg/ml)	2.5 (2.2-2.9)	3.0 (2.8-3.4)	<0.01	0.16
Log IL-10 (pg/ml)	2.2 (0.5-2.6)	2.9 (2.2-3.3)	<0.01	0.04*
Log IL-18 (pg/ml)	5.8 (5.4-6.2)	5.9 (5.6-6.1)	0.50	0.99
Log IP-10 (pg/ml)	5.9 (4.8-6.3)	6.1 (6.1-6.6)	0.01	0.18
Log TNFR1 (pg/ml)	7.1 (6.7-7.4)	7.6 (7.4-7.7)	<0.01	0.01*
Log MMP-8 (pg/ml)	7.5 (6.8-8.2)	8.6 (7.5-8.9)	0.02	0.24
Log Ang-1 (pg/ml)	8.5 (8.0-8.8)	8.7 (8.1-8.9)	0.90	0.99
Log Ang-2 (pg/ml)	7.1 (6.7-7.4)	7.2 (6.9-7.7)	0.32	0.97
Log P-selectin (ng/ml)	3.2 (2.8-3.6)	3.5 (3.4-3.9)	0.02	0.23
Log SPD (pg/ml)	8.3 (7.6-8.9)	8.4 (7.9-8.8)	0.62	0.99
Log VEGF (pg/ml)	3.1 (2.5-3.4)	3.1 (2.6-3.3)	0.82	0.99
Coagulation and Fibrinolysis Biomarkers
Log Thrombomodulin (pg/ml)	8.4 (8.2-8.6)	8.7 (8.3-8.9)	0.16	0.85
Log PAI-1 (ng/ml)	1.4 (0.9-1.8)	1.8 (1.2-2.6)	0.02	0.21
Protein C (% normal)	89 (55-113)	60 (55-92)	0.11	0.78
von Willebrand Factor (% activity)	218 (119-340)	297 (212-420)	0.03	0.34
Factor VIII (% activity)	92 (60-208)	156 (89-280)	0.18	0.86
Log tPA (pg/ml)	7.7 (7.1-8.2)	7.9 (7.5-8.2)	0.52	0.99
Plasminogen (% activity)	126 (108-138)	114 (104-134)	0.58	0.99
Antiplasmin, (% activity)	110 (95-122)	108 (102-126)	0.69	0.99

*denotes statistical significance (p<0.05) after adjustment for multiple comparisons using Sidak-Holm method.