Table 4.
Sensitivity and specificity of key biomarkers on presentation for predicting development of severe disease or death at 7 days using Youden index and cut-point analysis.
| Biomarker | Cut-point* | Sensitivity | Specificity | AUC |
|---|---|---|---|---|
| Log RAGE | 8.07 (3,197 pg/ml) | 0.87 | 0.93 | 0.90 |
| Log SARS-CoV-2 Viral Antigen | 8.38 (4,359 pg/ml) | 0.82 | 0.87 | 0.85 |
| Log IL-6 | 3.66 (39 pg/ml) | 0.88 | 0.72 | 0.80 |
| Log TNFR-1 | 7.29 (1,466 pg/ml) | 0.82 | 0.70 | 0.76 |
| Log- IL-10 | 2.53 (13 pg/ml) | 0.71 | 0.68 | 0.69 |
AUC,area under the receiver operator characteristic curve.
*Youden’s index to identify optimal cut-point, with natural log transformed raw values for each variable, corresponding raw concentration shown in parenthesis for reference.