Table 2.
Demographic and clinical characteristics of COVID-19 cases and matched controls (susceptibility and progression to severe COVID-19).
| Susceptibility to the virus |
Progression to severe COVID-19 |
|||
|---|---|---|---|---|
| Characteristic | Cases (N = 29,817) |
Controls (N = 56,785) |
Cases (N = 3060) |
Controls (N = 26,757) |
| Sex; n (%) | ||||
| Male | 12,674 (42.5) | 28,729 (50.6) | 1552 (50.7) | 11,122 (41.6) |
| Female | 17,143 (57.5) | 28,056 (49.4) | 1508 (49.3) | 15,635 (58.4) |
| Age, median (IQR) | 49 (34–67) | 73 (59–84) | 74 (59–84) | 47 (33–63) |
| Health professional; n (%) | 1316 (4.4) | 1260 (2.2) | 81 (2.6) | 1235 (4.6) |
| Comorbidities; n (%) | ||||
| Hypertension | 7847 (26.3) | 28,020 (49.3) | 1754 (57.3) | 6093 (22.8) |
| Diabetes | 3301 (11.1) | 10,920 (19.2) | 841 (27.5) | 2460 (9.2) |
| COPD | 1128 (3.8) | 4569 (8.0) | 398 (13.0) | 730 (2.7) |
| Obesity | 4790 (16.1) | 10,817 (19.0) | 889 (29.1) | 3901 (14.6) |
| Ischaemic heart disease | 1191 (4.0) | 4768 (8.4) | 359 (11.7) | 832 (3.1) |
| Cerebrovascular accident | 1144 (3.8) | 3874 (6.8) | 306 (10.0) | 838 (3.1) |
| Heart failure | 1108 (3.7) | 4030 (7.1) | 469 (15.3) | 639 (2.4) |
| Atrial fibrillation | 1501 (3.7) | 5769 (10.2) | 466 (15.2) | 1035 (3.9) |
| Chronic renal failure | 2437 (8.2) | 4316 (7.6) | 437 (14.3) | 678 (2.5) |
| Cancer | 2230 (7.5) | 7770 (13.7) | 529 (17.3) | 1701 (6.4) |
| Asthma | 2437 (8.2) | 3388 (6.0) | 285 (9.3) | 2152 (8.0) |
| Current smoker | 4845 (16.2) | 8532 (15.0) | 809 (26.4) | 4036 (15.1) |
ICU = intensive care unit; IQR= interquartile range; COPD = Chronic obstructive pulmonary disease.