Table 4.
Significantly enriched pathways in up/down regulated DEPs between Sema and HFD groups identified through KEGG pathway enrichment analysis.
| Terms | Count | p Value | FDR | richFactor | Accession | Sema/HFD DEPs Regulated Type |
|---|---|---|---|---|---|---|
| Antigen processing and presentation | 7 | 0.00013769 | 0.033596295 | 0.22580645 | P01899 P97372 P36371 P21958 P06339 Q9R233 P06332 | up |
| Human immunodeficiency virus 1 infection | 14 | 0.000609053 | 0.054097938 | 0.10447761 | P01899 Q60710 P36371 P21958 Q8CIH5 Q05144 P06339 Q9R233 P31938 P31750 Q3TBT3 Q9DB50 P06332 O35904 | up |
| Herpes simplex virus 1 infection | 12 | 0.000665139 | 0.054097938 | 0.11428571 | P01899 P36371 P21958 P06339 Q9R233 Q8R5F7 P31750 Q3TBT3 Q9EQU3 Q8VI93 O35904 Q9EP53 | up |
| Human cytomegalovirus infection | 13 | 0.001234466 | 0.075302447 | 0.1015625 | P01899 P36371 P21958 Q05144 P06339 Q9R233 P31938 P31750 P51675 Q3TBT3 O35904 A3KGF7 Q9EP53 | up |
| Acute myeloid leukemia | 6 | 0.003441545 | 0.13284056 | 0.15384615 | P42232 P31938 P10810 P31750 P17433 O35904 | up |
| Cell adhesion molecules | 7 | 0.003512205 | 0.13284056 | 0.13461539 | P01899 P06339 P13597 P15702 P06332 Q9Z261 P27573 | up |
| Primary immunodeficiency | 3 | 0.003983193 | 0.13284056 | 0.33333333 | P36371 P21958 P06332 | up |
| Natural killer cell mediated cytotoxicity | 7 | 0.004355428 | 0.13284056 | 0.12962963 | P01899 Q8CIH5 Q05144 P06339 P31938 P13597 O35904 | up |
| Human T-cell leukemia virus 1 infection | 10 | 0.005680549 | 0.150034667 | 0.09803922 | P01899 P42232 P06339 P31938 P13597 P31750 P27931 P17433 P06332 O35904 | up |
| Fc gamma R-mediated phagocytosis | 8 | 0.006148962 | 0.150034667 | 0.11111111 | Q8CIH5 Q05144 P08101 P31938 P28667 P31750 Q7TQF7 O35904 | up |
| ECM-receptor interaction | 10 | 3.35E-05 | 0.008284126 | 0.2173913 | Q05793 Q61292 P97927 P02469 Q60675 P09055 Q08857 P43406 O70309 Q03350 | down |
| PPAR signaling pathway | 10 | 0.000226586 | 0.025015808 | 0.1754386 | P41216 Q62417 Q05816 Q08857 P43883 Q9EPL9 Q8JZK9 P11152 Q9Z1P8 O54794 | down |
| Bacterial invasion of epithelial cells | 10 | 0.000303836 | 0.025015808 | 0.16949153 | P09055 P49817 Q9WVC3 Q8CHH9 P42208 Q8BZ98 Q8BHL5 Q6IRU5 Q61140 Q9QYY0 | down |
| Focal adhesion | 14 | 0.001675795 | 0.103480359 | 0.112 | Q71LX4 Q61292 P97927 P02469 P57780 Q60675 P09055 P49817 Q9WVC3 P43406 O70309 Q61140 Q03350 P70182 | down |
| Valine, leucine and isoleucine biosynthesis | 2 | 0.006098131 | 0.301247675 | 0.66666667 | Q8R238 P24288 | down |
| Small cell lung cancer | 7 | 0.011087266 | 0.44441595 | 0.12962963 | Q61292 P97927 P02469 Q60675 P09055 P43406 O89106 | down |
| Cholesterol metabolism | 5 | 0.014282383 | 0.44441595 | 0.15625 | Q08857 Q9Z0J0 P11152 Q9Z1P8 Q8C142 | down |
| Dilated cardiomyopathy | 6 | 0.014394039 | 0.44441595 | 0.13636364 | P48678 Q60675 P09055 P43406 O70309 P97490 | down |
| Arrhythmogenic right ventricular cardiomyopathy | 5 | 0.025679591 | 0.704762112 | 0.13513514 | P48678 Q60675 P09055 P43406 O70309 | down |
| Pentose phosphate pathway | 4 | 0.033096704 | 0.8174886 | 0.14814815 | P05064 Q00612 Q9D7G0 Q8R1Q9 | down |