Table 2.

Definitions of Clinical Measurements of Interest Obtained From the Segmentations

Imaging Modality	Biomarker	Definition	Measurements of Interest
ICGA	Polypoidal lesions	As segmented	Area
	BVN	As segmented	Area
SD-OCT	Retina	ILM–BM layers	Volume, average height
	Choroid	BM–CSI layers	Volume, average height
	SIRE	RPE–BM layer thickness > 15 μm or RPE layer roughness > 2 μm (within window of 400 μm length)	Volume, average height
	PED	RPE–BM layer thickness > 150 μm	Volume, maximum height
	EZ defects	Absence of EZ	Area
	IRF	As segmented	Volume, average height
	SRF	As segmented	Volume, average height
	Sub-RPE ring-like lesions	As segmented	Volume, average height

BM = Bruch’s membrane; BVN = branching vascular network; CSI = choroidal-scleral interface; EZ = ellipsoid zone; ICGA = indocyanine green angiography; ILM = inner limiting membrane; IRF = intraretinal fluid; PCV = polypoidal choroidal vasculopathy; PED = pigment epithelium detachment; RPE = retinal pigment epithelium; SD = spectral domain; SIRE = shallow irregular RPE elevation; SRF = subretinal fluid.