Table 2.
Main results of randomised trials for adult out-of-hospital cardiac arrest.
| Study | Patients | Treatment | Control |
ROSCa |
Mid-term survival (30 and 90 days) |
Mid-term favourable neurological outcome (30 and 90 days) |
Long-term survival (6 and 12 months) |
Long-term favourable neurological outcome (6 and 12 months) |
|||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Treatment | Control | Treatment | Control | Treatment | Control | Treatment | Control | Treatment | Control | ||||
| Stueven, 1985 (EMD)1 | 90 | Calcium | Saline | 8/48 (16.7%) | 2/42 (4.8%) | NR | NR | NR | NR | NR | NR | NR | NR |
| RR 3.5 (0.79–15.58) | |||||||||||||
| Stueven, 1985 (Asystole)2 | 73 | Calcium | Saline | 3/39 (7.7%) | 1/34 (2.9%) | 0/39 (0%)b | 0/34 (0%)b | NR | NR | NR | NR | NR | NR |
| RR 2.43 (0.26–22.31) | |||||||||||||
| Vallentin, 20219 & Vallentin, 202210 | 391 | Calcium | Saline | 37/193 (19%) | 53/198 (27%) | 10/193 (5.2%)c | 18/198 (9.1%)c | 7/193 (3.6%)c | 15/198 (7.6%)c | 10/193 (5.2%)e | 18/198 (9.1%)e | 8/193 (4.2%)e | 17/198 (8.6%)e |
| RR 0.72 (0.49–1.03) | RR 0.57 (0.27–1.18)c | RR 0.48 (0.20–1.12)c | RR 0.57 (0.27–1.18)e | RR 0.48 (0.22–1.07)e | |||||||||
| 10/193 (5.2%)d | 18/198 (9.1%)d | 7/193 (3.6%)d | 18/198 (9.1%)d | 9/193 (4.7%)f | 18/198 (9.1%)f | 7/193 (3.6%)f | 17/198 (8.6%)f | ||||||
| RR 0.57 (0.27–1.18)d | RR 0.40 (0.17–0.91)d | RR 0.51 (0.24–1.09)f | RR 0.42 (0.18–0.97)f | ||||||||||
EMD: Electromechanical dissociation; NR: Not reported; ROSC: Return of spontaneous circulation; RR: Risk ratio.
a
Defined as outcomes at ROSC.
b
Defined as outcomes at hospital discharge.
c
Defined as outcomes at 30 days.
d
Defined as outcomes at 90 days.
e
Defined as outcomes at 6 months.
f
Defined as outcomes at 12 months.