Table 3.
Certainty of evidence for randomised trials in adults with out-of-hospital cardiac arrest.
| Studies | Risk of Bias | Inconsistency | Indirectness | Imprecision | Othera | Overall |
|---|---|---|---|---|---|---|
| ROSC | ||||||
| Stueven, 1985 (EMD)1 | Serious | N/Ab | Not serious | Seriousc | None | Moderate |
| Stueven, 1985 (Asystole)2 | Serious | N/Ab | Not serious | Very seriousd | None | Very low |
| Vallentin, 20219 | Not serious | N/Ab | Not serious | Very seriousd | None | Very low |
| Survival to 1 months and 3 months | ||||||
| Vallentin, 20219 | Not serious | N/Ad | Not serious | Seriousc | None | Moderate |
| Favourable neurological outcome at 1 months and 3 months | ||||||
| Vallentin, 20219 | Not serious | N/Ae | Not serious | Seriousc | None | Moderate |
| Survival at 6 months and 12 months | ||||||
| Vallentin, 202210 | Not serious | N/Ae | Not serious | Seriousc | None | Moderate |
| Favourable neurological outcome at 6 months and 12 months | ||||||
| Vallentin, 202210 | Not serious | N/Ae | Not serious | Seriousc | None | Moderate |
EMD: Electromechanical dissociation; ROSC: Return of spontaneous circulation.
a
Includes assessment of publication bias and magnitude of the effect.
b
Cannot judge inconsistency because meta-analysis was not performed.
c
Confidence interval that includes one, and smaller than planned sample size as trial was stopped early.
d
Very small sample size, wide confidence interval.
e
Cannot judge inconsistency due to single trial.