TABLE 4.

Current EV-related clinical trials. Information is current as of 26 January 2023 and was found through clinicaltrials.gov by searching for clinical trials involving extracellular vesicles or exosomes.

Use	Disease	Cargo or target (if applicable)	Status	NCT identifier	Citation
Carrier and maintenance immunotherapy	Non-small cell lung cancer	Tumor antigens	Completed	NCT01159288	Besse et al. (2016)
Carrier	Pancreatic cancer	siRNA against KrasG12D	Recruiting	NCT03608631	Kamerkar et al. (2017)
Carrier	Hepatocellular carcinoma, gastric cancer liver metastases, and colorectal cancer	Anti-sense oligonucleotide targeting STAT6	Recruiting	NCT05375604	Kamerkar et al. (2022)
Biomarker	Lung metastases from osteosarcoma	RNA cargo characterization	Unknown	NCT03108677	Bao et al. (2018)
Biomarker	Lung cancer	-	Active	NCT04529915	-
Biomarker	Pancreatic cancer	-	Recruiting	NCT02393703	-
Biomarker	Lung cancer	-	Recruiting	NCT04629079	-
Biomarker	Gastric cancer	LncRNA-GC1	Recruiting	NCT05397548	Xin Guo et al. (2020)
Biomarker	Thyroid cancer	Thyroglobulin and Galectin-3	Recruiting	NCT04948437	-
Biomarker	Non-small cell lung cancer	-	Recruiting	NCT05424029	-
Biomarker	Lung cancer	-	Recruiting	NCT04939324	-
Predict response to anlotinib	Non-small cell lung cancer	-	Not yet recruiting	NCT05218759	-
Monitor disease	Sarcoma	RNA cargo characterization	Recruiting	NCT03800121	-
Immune evasion mechanism	Diffuse large B-cell lymphoma	Cargo characterization	Recruiting	NCT03985696	-
Screening tool	Oropharyngeal squamous cell carcinoma	-	Recruiting	NCT02147418	-
Immune evasion mechanism	Liver cancer	Cargo characterization	Recruiting	NCT05575622	-
Biomarker	Pancreatic adenocarcinoma	-	Recruiting	NCT03334708	-
Biomarker for disease progression	Thyroid cancer	-	Not yet recruiting	NCT05463107	-
Early detection	Breast cancer	miRNA characterization	Not yet recruiting	NCT05417048	-
Biomarkers for predicting treatment response	Small cell lung cancer	Long RNA characterization	Recruiting	NCT05191849	-