TABLE 2.
Pooled prevalence of frequent somatic mutations in NEPC
| Gene | Studies (no.) | Sample size | Pooled prevalence, % (95% CI) | I 2, % | Het. p |
|---|---|---|---|---|---|
| TP53 | 10 | 176 | 49.8 (37.3–62.3) | 57 | 0.01 |
| TTN | 2 | 52 | 26.9 (16.6–40.5) | 31 | 0.23 |
| DST | 1 | 30 | 23.3 (9.9–42.3) | ‐ | ‐ |
| MUC16 | 2 | 52 | 19.2 (10.7–32.2) | 0 | 0.39 |
| ZFHX4 | 1 | 30 | 13.3 (3.8–30.7) | ‐ | ‐ |
| ZNF479 | 1 | 30 | 13.3 (3.8–30.7) | ‐ | ‐ |
| CACNA1B | 1 | 30 | 13.3 (3.8–30.7) | ‐ | ‐ |
| ZNF99 | 2 | 52 | 12.7 (4.7–29.9) | 54 | 0.14 |
| CMYA5 | 2 | 52 | 11.5 (5.3–23.4) | 37 | 0.21 |
| RYR1 | 2 | 52 | 11.5 (5.3–23.4) | 0 | 0.64 |
| OBSCN | 2 | 52 | 11.5 (5.3–23.4) | 0 | 0.69 |
| KMT2D | 2 | 52 | 11.5 (5.3–23.4) | 0 | 0.69 |
| RYR2 | 2 | 52 | 11.5 (5.3–23.4) | 0 | 0.69 |
Note: Het = heterogeneity.