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. 2022 Dec 22;108(4):1141–1157. doi: 10.3324/haematol.2022.281006

Figure 3.

Figure 3.

Enhanced megakaryocyte maturation and proplatelet formation in patients with faster COX-1 recovery. Representative immunofluorescence of megakaryocytes (Mk) (A) and proplatelet formation (PPF) (B). The proportion of mature Mk was measured by flow cytometry, as the percentage and mean fluorescence intensity (MFI) of CD41-positive cells (healthy subjects n=5; first tertile: all n=8, type 2 diabetes mellitus (T2DM) n=4, no T2DM n=4; third tertile: all n=10, T2DM n=4, no T2DM n=6) (C, D); and as the percentage and MFI of GPIbα (CD42b)-positive cells (healthy subjects n=5; first tertile: all n=8, T2DM n=4, no T2DM n=4; third tertile: all n=11, T2DM n=5, no T2DM n=6) (C, D). PPF was quantified as the proportion of Mk displaying at least one proplatelet with respect to the total number of adhered Mk (healthy subjects n=5; first tertile: all n=7, T2DM n=4, no T2DM n=3; third tertile: all n=8, T2DM n=4, no T2DM n=4) (E).