Figure 6.

CD123.ENG.iMC and CD123.ENG.iM T cells have potent antitumor activity in vivo. MOLM-13.GFP.ffluc-bearing mice received a single intravenous dose of 1x10⁷ T cells on day 7 (n=10 animals per group, 2 T-cell donors for CD123.ENG, CD123.ENG iMC, CD123.ENG iM, or CD123.ENG iC T cells; n=5, 1 T-cell donor for CD19.ENG.iMC). Four doses of a chemical inducer of dimerization were given intraperitoneally every 3-4 days. (A) Experimental scheme and quantitative bioluminescence data for donor 1 and donor 2. (B) Kaplan-Meier survival curve (**P<0.01, log rank test). D0: day 0; D7: day 7; CID: chemical inducer of dimerization; ENG: engager; iMC: inducible MyD88 and CD40; iM: inducible MyD88; iC: inducible CD40;