Table 4:

Feature Importance Scores

Variable	Static or Dynamic Parameter*	Mean Permutation Feature Importance Score	Standard Deviation	p-value
Creatinine (Maximum)	Dynamic	0.1723	0.00213	<0.0001
Baseline Creatinine	Static	0.0159	0.00046	<0.0001
Cardiac Output (Minimum)	Dynamic	0.0033	0.00023	<0.0001
Creatinine (Minimum)	Dynamic	0.0031	0.00030	<0.0001
Nafcillin (Maximum dosage)	Dynamic	0.0029	0.00018	<0.0001
Cardiac Output (Maximum)	Dynamic	0.0025	0.00020	<0.0001
Age	Static	0.0019	0.00027	<0.0001
Calcium gluconate (Maximum dosage)	Dynamic	0.0018	0.00025	<0.0001
Central venous pressure (Maximum)	Dynamic	0.0016	0.00012	<0.0001
Chest tube output (Maximum)	Dynamic	0.0014	0.00010	<0.0001
Propofol (Maximum dosage)	Dynamic	0.0013	0.00008	<0.0001
Furosemide (Maximum dosage)	Dynamic	0.0012	0.00016	<0.0001
Gender	Static	0.0012	0.00015	<0.0001
Potassium chloride (Maximum dosage)	Dynamic	0.0010	0.00013	<0.0001
Nicardipine (Maximum dosage)	Dynamic	0.0010	0.00007	<0.0001
Chronic kidney disease	Static	0.0009	0.00023	0.0006
Anion gap (Minimum)	Dynamic	0.0009	0.00009	<0.0001
Chronic liver disease	Static	0.0009	0.00007	<0.0001
Famotidine (Maximum dosage)	Dynamic	0.0008	0.00008	0.0000
Metolazone (Maximum dosage)	Dynamic	0.0008	0.00017	0.0000

^*Dynamic parameters are input as the maximum (or minimum) value over the prior 24 hours, on a rolling basis. Static parameters are known prior to intensive care unit admission and remain constant throughout postoperative period