Figure 7.

Scaffolds derived from AC ECM can be used alone or in combination with exogenous growth factors for the repair of chondral lesions: (a) ECM biomaterial used in MSCs chondrogenic differentiation and 3D scaffolds fabrication, (b) AC ECM scaffolds used alone or in combination with TGF-β3 promotes the recapitulation of native collagen fiber alignment in the superficial zone, and shows better repair effect compared to traditional MFX therapy. Histological sections were stained with picrosirius red and then imaged using polarized light microscopy. Reproduced from Weng et al.¹⁴⁴