Table 2.
Seven genes which were involved in both infections of three coronaviruses and two neurodegenerative diseases, and the drug targeted against these genes.
| Gene | Gene full name | Num of drugs | Top 1 drug* | Mol. type of drug | Score# |
|---|---|---|---|---|---|
| HSP90AA1 | Heat shock protein 90 alpha family class A member 1 | 3 | ARGENTEOSIDE A | – | 0.94 |
| ALDH2 | Aldehyde dehydrogenase 2 family member | 5 | PRUNETIN | – | 12.73 |
| CAV1 | Caveolin 1 | 2 | TESTOSTERONE | Small Molecule | 1.77 |
| COMT | Catechol-O-methyltransferase | 12 | ENTACAPONE | Small Molecule | 16.91 |
| MTOR | Mechanistic target of rapamycin kinase | 4 | RIDAFOROLIMUS | Small Molecule | 1.13 |
| IGF2R | Insulin like growth factor 2 receptor | 1 | MANNOSE 6-PHOSPHATE | – | 127.3 |
| HSPA1A | Heat shock protein family A (Hsp70) member 1A | 1 | CARBAMAZEPINE | Small Molecule | 2.71 |
“-”, no data available.
“*”, the drug with the top interaction score.
“#”, the gene-drug interaction scores provided in the DGIdb database which reflect the confidence and specificity of the gene-drug interactions. The larger, the better. Please see Table S7 for more gene-drug interactions.