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. 2023 Feb 1;31(3):417–432. doi: 10.1016/j.jsps.2023.01.009

Fig. 4.

Fig. 4

(A) Observations of the percentage hemolysis as a function of time for Rivastigmine, blank (MCM-41B) and Rivastigmine-loaded MCM-41 (MCM-41L); (B) In vivo pharmacokinetic plasma profile of Rivastigmine and MCM-41L and (C) In vivo brain distribution of Rivastigmine and MCM-41L in Wistar rats. (D) An assessment of the content of SiNPs in the brains of rats (n = 6) following 1 and 7 days of intranasal instillation of SiNPs. (E) Dose-dependent apoptosis and necrosis in PC12 cells induced by SiNPs. (F) A western blot densitometric analysis of SiNP-induced expression of p53, p-p53, p21, Gadd45, bax, and bcl-2 in PC12 cells. This Figure was reproduced under Creative Commons licenses from ref. (Pandey et al., 2018, Wu et al., 2011).