Table 2.

Outcomes by PICO question.

Outcomes	Adult and Pediatric Patient Populations
	Isolated RBD	Secondary RBD due to Medical Condition	Drug-induced RBD
Frequency of significant bed partner sleep disruption	√*	√*	√*
Frequency and/or intensity of dream enactment episodes	√*	√*	√*
Treatment-related worsening in sedation or cognitive impairment	√*	√*	√*
Treatment-related worsening in gait stability	√*	√*	√*
Treatment-related worsening in symptoms of depression or anxiety	√*	√*	√*
Frequency and/or intensity of unpleasant dreams and nightmares	√	√	√
Change in REM motor tone—tonic and/or phasic	√	√	√
Quality of life	√	√	√
Sleep quality	√	√	√
Daytime motor function	√	√	√

^*Critical outcomes. PICO = Population, Intervention, Comparison, Outcome, RBD = rapid eye movement sleep behavior disorder, REM = rapid eye movement.