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. Author manuscript; available in PMC: 2023 Apr 4.
Published in final edited form as: Hepatology. 2021 Aug 30;74(3):1652–1659. doi: 10.1002/hep.31765

Fig.1. Regulation of H19 and Igf2 expression.

Fig.1.

A) H19 is expressed from the maternal allele. The binding of CTCF to the unmethylated imprinting control region (ICR) prevents the down-stream enhancer from interacting with the promoter region of Igf2 but allows the enhancer to interact with the H19 promoter. The H19 transcript contains five exons. In exon 1, there is the coding region for miR675. The production of pre-miR675 is inhibited by RBP HuR. B) In the parental allele, the ICR is methylated, which prevents the binding of CTCF and allows the enhancer to interact with the promoter region of Igf2. DMR; DNA methylation region; ICR: imprinting control region; CTCF: CCCTC binding factor.