Table 3.
Buprenorphine vs Buprenorphine + Naloxone Comparisons.
| IV Challenge Dose | Bup 1.51 Vs Bup/Nx 1.51/0.44 | Bup 2.16 Vs Bup/Nx 2.16/0.61 | Bup 6.15 Vs Bup/Nx 6.15/1.71 | Bup 8.64 Vs Bup/Nx 8.64/2.44 | ||
|---|---|---|---|---|---|---|
| Drug Self-Administration: Mean Difference (95% Confidence Interval) | ||||||
| - % Drug Choices | 17.7 (−0.29 to 35.7) | 8.46 (−10.9 to 27.9) | 15.4 (−3.9 to 34.7) | 13.8 (−10.0 to 37.7) | ||
| - Drug Breakpoint | 365.4 (−46.9 to 777.7) | 246.2 (−201.1 to 693.4) | 338.5 (−133.2 to 810.1) | 430.8 (−120.5 to 982.1) | ||
|
Positive Subjective Effects
| ||||||
| Drug Effects Questionnaire (0–4): Mean Difference (95% Confidence Interval) | ||||||
| - Good | 0.31 (−0.32 to 0.93) | 0.23 (−0.21 to 0.67) | 1.08 (0.40 to 1.75) | 1.00 (0.51 to 1.49) | ||
| - Like | 1.00 (0.26 to 1.74) | 0.31 (−0.69 to 1.31) | 1.46 (0.78 to 2.14) | 1.62 (0.85 to 2.38) | ||
| - Take Again | 1.08 (0.28 to 1.88) | 0.54 (−0.34 to 1.42) | 1.54 (0.63 to 2.45) | 0.85 (0.07 to 1.620) | ||
| Visual Analog Scale (0–100): Mean Difference (95% Confidence Interval) | ||||||
| - Good | 9.85 (−0.74 to 20.44) | 2.00 (−6.79 to 10.79) | 20.62 (−1.73 to 42.69) | 18.23 (−1.42 to 37.88) | ||
| - High | −1.23 (−20.93 to 18.47) | 4.85 (−17.85 to 27.55) | 18.69 (2.85 to 34.54) | 8.08 (−7.48 to 23.63) | ||
| - Liked the Choice | 22.1 (1.84 to 42.3) | 11.6 (−4.66 to 27.9) | 21.1 (-0.15 to 42.5) | 7.62 (−14.0 to 29.2) | ||
| - Would Pay | 2.15 (−0.37 to 4.344) | 2.62 (−0.99 to 6.22) | 5.08 (1.07 to 9.09) | 2.92 (−1.56 to 7.41) | ||
| Aversive Subjective Effects | ||||||
| Drug Effects Questionnaire (0–4): Mean Difference (95% Confidence Interval) | ||||||
| - Bad | −2.39 (−3.45 to −1.32) | −1.85 (−2.83 to −0.86) | −2.23 (−3.49 to −0.97) | −2.08 (−3.19 to −0.96) | ||
| Subjective Opioid Withdrawal Scale (0–64): Mean Difference(95% Confidence Interval) | ||||||
| - Sum Score | −10.5 (−20.0 to −0.89) | −16.5 (−27.3 to −5.76) | −15.2 (−21.1 to −9.36) | −24.3 (−34.7 to −13.9) | ||
| Visual Analog Scale (0–100): Mean Difference(95% Confidence Interval) | ||||||
| - Bad | −30.8 (−56.5 to −5.17) | −46.8 (−68.1 to −25.5) | −48.2 (−75.1 to −21.3) | −60.8 (−85.1 to −36.6) | ||
| - Nauseated | −18.4 (−39.2 to 2.39) | −23.7 (−42.5 to −4.87) | −19.1 (−40.9 to 2.81) | −25.8 (−44.2 to −7.31) | ||