Table 5.
Diagnostic performance of imaging indicators for hemodynamically significant CAD.
| Indicator | AUC (95% CI) | Best cutoffs | Youden index | Sensitivity, % (95% CI) | Specificity, % (95% CI) | PPV, % (95% CI) | NPV, % (95% CI) |
|---|---|---|---|---|---|---|---|
| CACs | 0.699 (0.641–0.752) | >58.7 | 0.341 | 75.9 (66.9–83.5) | 58.2 (50.3–65.8) | 55.2 (50.0–60.3) | 78.0 (71.4–83.5) |
| EAT volume, cm3 | 0.727 (0.670–0.779) | >120.74 | 0.397 | 67.0 (57.4–75.6) | 72.7 (65.3–79.4) | 62.5 (55.7–68.8) | 76.4 (71.0–81.1) |
| Obstructive CAD | 0.891 (0.848–0.925) | 0.782 | 98.2 (93.7–99.8) | 80.0 (73.1–85.8) | 76.9 (71.0–81.9) | 98.5 (94.3–99.6) | |
| EAT + CACs | 0.766 (0.712–0.815) | >0.389 | 0.439 | 70.5 (61.2–78.8) | 73.3 (65.9–79.9) | 64.2 (57.6–70.4) | 78.6 (73.1–83.2) |
| CACs + Obstructive CAD | 0.902 (0.861–0.935) | >0.025 | 0.782 | 98.2 (93.7–99.8) | 80.0 (73.1–85.8) | 76.9 (71.0–81.9) | 98.5 (94.3–99.6) |
| EAT + Obstructive CAD | 0.950 (0.917–0.973) | >0.526 | 0.807 | 92.9 (86.4–96.9) | 87.9 (81.9–92.4) | 83.9 (77.5–88.7) | 94.8 (90.3–97.3) |
AUC, area under curve; CACs, coronary artery calcium score; CAD, coronary artery disease; CI, confidence interval; EAT, epicardial adipose tissue; NPV, negative predictive value; PPV, positive predictive value.