Table 1.

Data collection and refinement statistics

	ENL T1 YEATS-H3K27ac (PDB code: 7X8B)	ENL T2 YEATS-H3K27ac (PDB code: 7X88)	ENL T3 YEATS-H3K27ac (PDB code: 7E74)	ENL T4 YEATS-H3K27ac (PDB code: 7X8F)	ENL T1(H116P) YEATS-H3K27ac (PDB code: 7X8G)
Data collection
Space group	C2	P3121	P212121	C2	C2C2
Cell dimensions
a, b, c (Å)	156.7, 48.7,	52.1, 52.1,	82.8, 91.3,	156.6, 48.6,	155.1, 48.5,
	47.7	136.4	165.8	47.3	47.8
a, β, γ(°)	90, 101, 90	90,90,120	90,90,90	90, 101, 90	90, 101, 90
Unique reflections	15861(1466)	10730(994)	28461(2770)	13193(1305)	27089(2697)
Resolution Å)	30.00–2.30	50.00–2.25	50.00–2.91	40.00–2.45	30.00–1.90
	(2.34–2.30)	(2.29–2.25)	(2.96–2.91)	(2.49–2.45)	(1.93–1.90)
R sym	0.091(0.333)	0.132(0.735)	0.239(0.955)	0.149(0.931)	0.124(0.423)
I/σ(I)	37.2(13.4)	32.7(3.0)	8.3(2.0)	11.4(1.3)	17.7(5.0)
Completeness (%)	98.7(92.4)	99.1(96.8)	99.5(98.0)	99.8(99.0)	99.1(99.0)
CC1/2	0.992(0.932)	0.999(0.960)	0.984(0.863)	0.987(0.571)	0.975(0.924)
Redundancy	5.1(5.5)	15.2(7.7)	13.1(13.4)	6.4(5.0)	6.5(6.4)
Refinement
Resolution (Å)	17.29–2.23	45.16–2.25	44.02–2.91	38.40–2.45	25.79–1.90
No. reflections	15858	10676	28455	13189	27077
Rwork/Rfree	18.8/22.6	21.3/24.4	20.4/24.4	20.2/25.2	19.7/21.6
No. atoms
Protein	2467	1193	5697	2541	2470
Ligand	/	13	/	1	/
Solvent	122	16	7	42	250
B factors
Protein	31.5	50.9	45.9	52.8	30.0
Ligand	/	80.7	/	51.1	/
Solvent	32.8	49.9	33.1	47.8	36.0
R.m.s. deviations
Bond lengths (Å)	0.009	0.015	0.012	0.011	0.00.009
Bond angles (°)	0.97	1.54	1.26	1.32	1.24
Ramchandran
Statistics(%)
Favored	99.3	97.1	97.2	97.6	99.0
Allowed	0.0	2.9	1.9	2.1	1.01.0
Outliers	0.7	0.0	0.9	0.3	0.00.0

Values in parentheses are for highest-resolution shell.