| N ASD | N Other disorders | Sensitivity 95% CI | Specificity 95% CI | LR+ | LR− | |||
|---|---|---|---|---|---|---|---|---|
| TP | FN | TN | FP | |||||
| Total | ||||||||
| ADOS | 59 | 6 | 226 | 48 | 91%, 81–97 | 83%, 78–87 | 5 | 0.11 |
| ADI-research (res) | 30 | 35 | 262 | 12 | 46%, 34–59 | 96%, 93–98 | 11 | 0.56 |
| ADI-clinical (clin) | 44 | 21 | 247 | 27 | 68%, 55–79 | 90%, 86–93 | 7 | 0.36 |
| ADI-clin & ADOS | 39 | 26 | 265 | 9 | 60%, 47–72 | 97%, 94–99 | 18 | 0.41 |
| ADI-clin or ADOS | 64 | 1 | 208 | 66 | 99%, 92–100 | 76%, 70–81 | 4 | 0.02 |
| Phrase-speech (PS) | ||||||||
| ADOS | 31 | 3 | 176 | 28 | 91%, 76–98 | 86%, 81–91 | 7 | 0.10 |
| ADI-res | 11 | 23 | 198 | 6 | 32%, 17–51 | 97%, 94–99 | 11 | 0.70 |
| ADI-clin | 20 | 14 | 190 | 14 | 59%, 41–75 | 93%, 89–96 | 9 | 0.44 |
| ADI-clin & ADOS | 17 | 17 | 198 | 6 | 50%, 32–68 | 97%, 94–99 | 17 | 0.52 |
| ADI-clin or ADOS | 34 | 0 | 168 | 36 | 100%, 90–100 | 82%, 76–87 | 6 | <0.01 |
| Single words (SW) | ||||||||
| ADOS | 17 | 3 | 40 | 16 | 85%, 62–97 | 71%, 58–83 | 3 | 0.21 |
| ADI-res | 11 | 9 | 51 | 5 | 55%, 32–77 | 91%, 80–97 | 6 | 0.49 |
| ADI-clin | 16 | 4 | 44 | 12 | 80%, 56–94 | 79%, 66–88 | 4 | 0.25 |
| ADI-clin & ADOS | 14 | 6 | 53 | 3 | 70%, 46–88 | 95%, 85–99 | 13 | 0.32 |
| ADI-clin or ADOS | 19 | 1 | 31 | 25 | 95%, 75–100 | 55%, 42–69 | 2 | 0.09 |
| Nonverbal (NV) | ||||||||
| ADOS | 11 | 0 | 10 | 4 | 100%, 72–100 | 71%, 42–92 | 4 | <0.01 |
| ADI-res | 8 | 3 | 13 | 1 | 73%, 39–94 | 93%, 66–100 | 10 | 0.29 |
| ADI-clin | 8 | 3 | 13 | 1 | 73%, 39–94 | 93%, 66–100 | 10 | 0.29 |
| ADI-clin & ADOS | 8 | 3 | 14 | 0 | 73%, 39–94 | 100%, 77–100 | na | 0.27 |
| ADI-clin or ADOS | 11 | 0 | 9 | 5 | 100%, 72–100 | 64%, 35–87 | 3 | <0.01 |
ADI, autism diagnostic interview-revised; ADOS, autism diagnostic observation schedule; ASD, autism spectrum disorder; LR+, positive likelihood ratio; LR−, negative likelihood ratio. TP=true positives, TN=true negatives, FP, false positives; FN, false negatives; CI, confidence interval.
ADI-research cutoffs: NV = 13, SW = 13, PS = 16. ADI-clinical cutoffs: NV = 11, SW = 8, PS = 13. ADOS-2 ASD cutoff: Module 1-no words = 11, Module 1-some words=8, Module 2-phrase-speech = 7.