Table 2.

Determinants of CSVD burden in multivariate models^a.

Variables	OR (95% CI)	p
Model 1
Hypertension	1.13 (1.03–1.64)	0.012
CrCP	1.30 (1.14–1.49)	<0.001
Model 2
Hypertension	1.14 (1.02–1.98)	0.047
CrCP	1.38 (1.16–1.66)	<0.001
Model 3
Hypertension	1.08 (1.01–1.47)	0.005
CrCP	1.29 (1.13–1.47)	<0.001
Model 4
Hypertension	1.06 (1.00–1.63)	0.020
CrCP	1.41 (1.17–1.71)	<0.001

OR, odds ratio; CI, confidence interval; CrCP, critical closing pressure; CSVD, cerebral small vessel disease.

^aModel 1 adjusted for age, sex, and significant (P < 0.05) variables from the univariate analyses (Including age, hypertension, systolic blood pressure, diastolic blood pressure, mean blood pressure, pulse pressure, and CrCP); Model 2 adjusted for age, sex, vascular risk factors (Including hypertension, diabetes mellitus, coronary artery disease, current or recent smoking history, alcohol consumption history, BMI, triglyceride, cholesterol, low density lipoprotein, and Glucose) and significant variables from the univariate analyses; Model 3 adjusted for age, sex, hemodynamics (Including systolic blood pressure, diastolic blood pressure, mean blood pressure, pulse pressure, PSV, MFV, PI, and CrCP) and significant variables from the univariate analyses; and Model 4 adjusted for age, sex, vascular risk factors, hemodynamics and significant variables from the univariate analyses.