Table 2.
Regional 11C-PiB SUVR values for APOE ε4 homozygotes, heterozygotes, and non-carriers
| Region | 11C-PiB binding (SUVR) | ε4ε4 vs ε3ε3 | ε4ε4 vs ε4ε3 | ε4ε3 vs ε3ε3 | |||
|---|---|---|---|---|---|---|---|
| APOEε4ε4 | APOEε4ε3 | APOEε3ε3 | Pa | Pb | Pb | Pb | |
| Prefrontal cortex | 2.23 (1.65–2.89) | 1.51 (1.40–1.99) | 1.43 (1.35–1.65) | 0.0007 | 0.0007 | 0.023 | 0.84 |
| Parietal cortex | 2.34 (1.71–2.79) | 1.70 (1.48–2.21) | 1.56 (1.47–1.75) | 0.0098 | 0.011 | 0.071 | 1.00 |
| Anterior cingulum | 2.42 (1.70–3.04) | 1.73 (1.54–2.20) | 1.56 (1.47–1.73) | 0.0007 | 0.0005 | 0.064 | 0.37 |
| Posterior cingulum | 2.43 (1.74–3.15) | 1.76 (1.59–2.23) | 1.64 (1.57–1.89) | 0.016 | 0.017 | 0.12 | 1.00 |
| Precuneus | 2.84 (1.80–3.23) | 1.79 (1.57–2.49) | 1.68 (1.60–1.91) | 0.0041 | 0.004 | 0.057 | 1.00 |
| Lateral temporal cortex | 1.78 (1.49–2.50) | 1.44 (1.30–1.67) | 1.35 (1.28–1.50) | 0.0053 | 0.0043 | 0.11 | 0.77 |
| Cortical composite | 2.13 (1.61–2.83) | 1.55 (1.43–2.02) | 1.47 (1.38–1.66) | 0.0024 | 0.002 | 0.056 | 0.82 |
Data presented as median (interquartile range)
Pa, Kruskal–Wallis test; Pb, Dunn's method for pairwise comparisons