FIGURE 2.

MACROPATATE stably chelates ²²⁵Ac and binds to SSTR. (A) Representative ITLC chromatogram of ²²⁵Ac-MACROPATATE. (B) Intact conjugate remaining over time of ²²⁵Ac-MACROPATATE and ²²⁵Ac-DOTATATE in human serum incubated at 37°C, as measured by ITLC. (C) Percentage of initial intact conjugate remaining over time, normalized to starting amount, after incubation in human serum at 37°C. (D) Assessment of SSTR2 binding affinity of ²²⁵Ac-MACROPATATE in U2-OS SSTR2 cells using saturation binding assay.