FIGURE 5.

Therapeutic response of mice bearing H69 lung NET xenografts treated with ²²⁵Ac-MACROPATATE (46 kBq), ²²⁵Ac-DOTATATE (148 kBq), or vehicle control shows that targeted α-therapy with ²²⁵Ac-MACROPATATE and ²²⁵Ac-DOTATATE is effective. (A) Tumor volume measurements over time. Solid lines represent average volume, and dashed lines represent 95% CI. Plots for each dataset are discontinued after first mouse death due to excessive tumor volume. Full tumor volume measurements for study duration for each mouse are reported in Supplemental Figures 15–17. (B) Maximal response to treatment (tumor volume growth percentage) of individual mice. Nonresponding mice are represented as full tumor growth (2,000% increase). (C) Mouse survival over time. Endpoint was defined as tumor volume > 2,000 mm³ or weight loss over 20% of starting weight. (D) Average mouse body weights over time for each treatment group. Error bars represent SD. ***P < 0.005. *P < 0.05.