FIGURE 3.

[¹⁸F]MK6240 age-related retention. (A) [¹⁸F]MK6240 average SUVR images in CUY and CU Aβ− individuals did not seem to show strong differences visually. t test between 2 groups depicts age-related retention in putamen, pallidum, cortical regions, and cerebellar white matter. (B) Percentage of overlap between age-related t-map and anatomic brain regions. (C) Longitudinal changes (ΔSUVR) in [¹⁸F]MK6240 SUVR in putamen/pallidum did not present significant differences across groups, whereas cross-sectional SUVR was higher in CI individuals and lower in CUY group. ***P < 0.001. **P < 0.005. Δ = change calculated as $\frac{(\text{follow-up} \text{SUVR}\hspace{0.17em}-\hspace{0.17em}\text{baseline} \text{SUVR})}{\text{time} \left(\text{y}\right)};$ WM = white matter.