TABLE 1.

Regions for Visual Assessment

Brain area	Included regions	Visual rating	No. regions	Rationale
Cluster 1, temporal lobes	Hippocampus; mesial temporal; inferior temporal; lateral temporal	No uptake (0%); uptake 1%–25%; extension 26%–75%; >75% extension	8 regions: 4 each in left and right hemispheres	Earliest cortical regions involved in AD per Braak staging
Cluster 2, extratemporal neocortex	Occipital; posterior cingulate; parietal; frontal	No uptake (0%); uptake 1%–25%; extension 26%–75%; >75% extension	8 regions: 4 each in left and right hemispheres	Next regions involved in AD
Cluster 3, subcortical area	Striatum-globus; thalamus; dentate nucleus; pons; midbrain	Presence or absence	5 regions	May be positive in non-AD tauopathies