FIGURE 2.

³H-flortaucipir, ³H-MK-6240, and ³H-PI-2620 binding in CTE IV. Total ³H-flortaucipir signal (5 nM), displacement by 10 μM clorgyline to block off-target binding to MAO-A, total ³H-MK-6240 (5 nM) binding, and total ³H-PI-2620 (6 nM) binding are compared with AT8 immunostaining for phospho-tau at 2-mm and 200-μm scales in CTE IV and AD.