Optimization of reaction conditions.
| ||||
|---|---|---|---|---|
| Entry | Cat. (mol%) | Solvent | Time (min) | Yielda (%) |
| 1 | — | H2O | 30 | N.R. |
| 2 | Bentonite@MgFe2O4@PGSA/Cu (0.2) | DMF | 30 | 80 |
| 3 | Bentonite@MgFe2O4@PGSA/Cu (0.2) | Toluene | 60 | 68 |
| 4 | Bentonite@MgFe2O4@PGSA/Cu (0.2) | EtOH | 15 | 90 |
| 5 | Bentonite@MgFe2O4@PGSA/Cu (0.2) | Solvent-free | 30 | 72 |
| 6 | Bentonite@MgFe2O4@PGSA/Cu (0.2) | H2O | 10 | 98 |
| 7 | Bentonite@MgFe2O4@PGSA/Cu (0.1) | H2O | 10 | 73 |
| 8 | Bentonite@MgFe2O4@PGSA/Cu (0.3) | H2O | 10 | 96 |
| 9b | Bentonite@MgFe2O4 (0.05 g) | H2O | 30 | 65 |
| 10c | PGSA (0.05 g) | H2O | 30 | 55 |
| 11d | Bentonite@MgFe2O4 @PGSA (0.05 g) | H2O | 20 | 83 |
| 12e | Bentonite@MgFe2O4/Cu (0.2) | H2O | 30 | 75 |
a
Isolated yield.
b
The model reaction was examined in the presence of Bentonite@MgFe2O4.
c
The model reaction was examined in the presence of PGSA.
d
The model reaction was examined in the presence of Bentonite@MgFe2O4 @PGSA.
e
The model reaction was examined in the presence of Bentonite@MgFe2O4/Cu.