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| Mutation | PDB code | Solubility | Structure | H11–H12 loop | Leu881 |
|---|---|---|---|---|---|
| Wild type | Yes | Yes | Closed | Rotamer 2 | |
| L702H/H875Y/F877L/T878A | 8fgy | Yes | Yes | Open | Rotamer 1 |
| L702H/H875Y/F877L | 8fgz | Yes | Yes | Open | Rotamer 1 |
| H875Y/F877L/T878A | 8fh0 | Yes | Yes | Closed | Rotamer 2 |
| L702H/H875Y | 8fh2 | Yes | Yes | Closed | Rotamer 2 |
| L702H/F877L | Low | No | — | — | |
| F877L/T878A | 8fh1 | Yes | Yes | Closed | Rotamer 2 |
| L702H | Low | No | — | — |
