Table 1.
Diagnostic criteria | Wilson disease | Non-Wilson disease |
---|---|---|
Phenotype (≥1) | ||
Hepatic | + | + |
| ||
Neurologic | + | + |
| ||
Other | + | + |
| ||
Clinical feature | ||
| ||
KF rings (slit lamp examination) | ± | − |
| ||
Laboratory values | ||
| ||
Serum caeruloplasmin | <0.2 g/L | ≥0.2 g/L |
| ||
Urinary copper | >2×ULN | ≤2×ULN (normal) |
| ||
Urinary copper, post penicillamine (if done) | >5×ULN | ≤5×ULN (normal) |
| ||
Liver biopsy (if done) | + | − |
KF: Kayser-Fleischer, ULN: upper limit of normal