Figure 1.
Example cells from the variable θNa population representing each case of susceptibility observed. Top: transmembrane voltage (Vm) trace over 1 beat for the example cell. Bottom: scaled conductance (θ) of the 13 ionic currents for the example cell. The 6 conditions of susceptibility are susceptible to no mutations (A), susceptible to ΔKPQ only (B), susceptible to I1768V only (C), susceptible to both Y1795C and ΔKPQ (D), susceptible to ΔKPQ and I1768V (E), and susceptible to all mutations (F). Wild-type (WT) traces are shown in black for each individual, incorporating 1 of the WT channel model published with each mutant model (denoted in parentheses).