Figure 11.
Trends in susceptibility from the fixed θNa population based on the combined expression of four major currents: IKr, IKs, ICa,L, and IK1. A–D: number of cells in a given subgroup with one of 16 combinations of high and low conductance. E–H: fraction of cells with a given high- and low-conductance combination that are seen in the given subpopulation. Cells with high θKr are almost exclusively seen in the zero susceptible subgroup. Cells are susceptible to all mutations only when θKr and θKs are both low (−) and, more frequently, when θCa,L is low (−).