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Trends for cells susceptible to only I1768V (A and C) and only ΔKPQ (B and D) in the fixed θNa population based on the combined expression of 4 major currents: IKr, IKs, ICa,L, and IK1. Cells are most likely to be susceptible to I1768V only when θKr, θCa,L, and θK1 are low (−) and θKs is high (+). Cells are most likely to be susceptible to ΔKPQ only when θKr, θCa,L and θKs are low (−) and θK1 is high (+). Cells are also frequently susceptible to ΔKPQ only when θCa,L is high (+).
